› 2w08

X-ray diffraction
1.7Å resolution

The structure of serum amyloid P component bound to 0-phospho- threonine

Released:
DOI: 10.2210/pdb2w08/pdb
PDB entry 2w08 coloured by chain, front view.
PDB entry 2w08 coloured by chain, side view.
PDB entry 2w08 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Molecular dissection of Alzheimer's disease neuropathology by depletion of serum amyloid P component.
Kolstoe SE, Ridha BH, Bellotti V, Wang N, Robinson CV, Crutch SJ, Keir G, Kukkastenvehmas R, Gallimore JR, Hutchinson WL, Hawkins PN, Wood SP, Rossor MN, Pepys MB
Proc Natl Acad Sci U S A 106 7619-23 (2009)
PMID: 19372378

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo pentamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-136123 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Serum amyloid P-component Chains: A, B, C, D, E
Molecule details ›
Chains: A, B, C, D, E
Length: 204 amino acids
Theoretical weight: 23.28 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P02743 (Residues: 20-223; Coverage: 100%)
Gene names: APCS, PTX2
Sequence domains: Pentaxin family
Structure domains: Jelly Rolls

Ligands and Environments

3 bound ligands:
Ligand CA 10 x CA
Ligand NAG 5 x NAG
Ligand TPO 5 x TPO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-2
Spacegroup: P21
Unit cell:
a: 94.769Å b: 69.435Å c: 102.063Å
α: 90° β: 97.05° γ: 90°
R-values:
R R work R free
0.154 0.154 0.176

Quick links

Citations

12 review citations

Protein aggregation diseases: pathogenicity and therapeutic perspectives.
Aguzzi et al. (2010)
11 more

1 mention without citation

Molecular dissection of Alzheimer's disease neuropathology by depletion of serum amyloid P component.
Kolstoe et al. (2009)