› 2w0i

X-ray diffraction
1.8Å resolution

Structure Of C-Terminal Actin Depolymerizing Factor Homology (Adf-H) Domain Of Human Twinfilin-2

Released:
DOI: 10.2210/pdb2w0i/pdb
PDB entry 2w0i coloured by chain, front view.
PDB entry 2w0i coloured by chain, side view.
PDB entry 2w0i coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Elkins JM, Pike ACW, Salah E, Savitsky P, Murray JW, Roos A, von Delft F, Edwards A, Arrowsmith CH, Wikstrom M, Bountra C, Knapp S

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-179753 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Twinfilin-2 Chain: A
Molecule details ›
Chain: A
Length: 135 amino acids
Theoretical weight: 15.72 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q6IBS0 (Residues: 179-313; Coverage: 39%)
Gene names: MSTP011, PTK9L, TWF2
Sequence domains: Cofilin/tropomyosin-type actin-binding protein
Structure domains: Severin

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: P6122
Unit cell:
a: 64.308Å b: 64.308Å c: 136.811Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.189 0.186 0.236
Expression system: Escherichia coli BL21(DE3)

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