› 2w50

X-ray diffraction
1.6Å resolution

N-terminal domain of human conserved dopamine neurotrophic factor (CDNF)

Released:
DOI: 10.2210/pdb2w50/pdb
PDB entry 2w50 coloured by chain, front view.
PDB entry 2w50 coloured by chain, side view.
PDB entry 2w50 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The structure of the conserved neurotrophic factors MANF and CDNF explains why they are bifunctional.
Parkash V, Lindholm P, Peränen J, Kalkkinen N, Oksanen E, Saarma M, Leppänen VM, Goldman A
Protein Eng Des Sel 22 233-41 (2009)
PMID: 19258449

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-175410 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cerebral dopamine neurotrophic factor Chains: A, B
Molecule details ›
Chains: A, B
Length: 102 amino acids
Theoretical weight: 11.75 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q49AH0 (Residues: 32-133; Coverage: 63%)
Gene names: ARMETL1, CDNF
Sequence domains: ARMET, N-terminal
Structure domains: Saposin-like

Ligands and Environments

1 bound ligand:
Ligand PO4 4 x PO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-3
Spacegroup: P21
Unit cell:
a: 48.3Å b: 42.04Å c: 51.99Å
α: 90° β: 97.67° γ: 90°
R-values:
R R work R free
0.21 0.209 0.24
Expression system: Spodoptera frugiperda

Quick links

Citations

24 review citations

Novel CDNF/MANF family of neurotrophic factors.
Lindholm et al. (2010)
23 more

2 mentions without citation

The Solution Structure and Dynamics of Full-length Human Cerebral Dopamine Neurotrophic Factor and Its Neuroprotective Role against α-Synuclein Oligomers.
Latge et al. (2015)
1 more