› 2w5r

X-ray diffraction
1.7Å resolution

Structure-based mechanism of lipoteichoic acid synthesis by Staphylococcus aureus LtaS.

Released:
DOI: 10.2210/pdb2w5r/pdb
Model geometry
Fit model/data
PDB entry 2w5r coloured by chain, front view.
PDB entry 2w5r coloured by chain, side view.
PDB entry 2w5r coloured by chain, top view.
Source organism: Staphylococcus aureus
Primary publication:
Structure-based mechanism of lipoteichoic acid synthesis by Staphylococcus aureus LtaS.
Lu D, Wörmann ME, Zhang X, Schneewind O, Gründling A, Freemont PS
Proc Natl Acad Sci U S A 106 1584-9 (2009)
PMID: 19168632

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-181311 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Processed glycerol phosphate lipoteichoic acid synthase Chain: A
Molecule details ›
Chain: A
Length: 424 amino acids
Theoretical weight: 48.84 KDa
Source organism: Staphylococcus aureus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q7A1I3 (Residues: 218-641; Coverage: 66%)
Gene names: MW0681, ltaS
Sequence domains: Sulfatase
Structure domains:

Ligands and Environments

3 bound ligands:
Ligand ACT 1 x ACT
Ligand MN 1 x MN
Ligand GP9 1 x GP9
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: DIAMOND BEAMLINE I04
Spacegroup: P212121
Unit cell:
a: 47.817Å b: 57.133Å c: 160.631Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.17 0.168 0.205
Expression system: Escherichia coli

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Citations

10 review citations

Lipoteichoic acid synthesis and function in gram-positive bacteria.
Percy et al. (2014)
9 more

2 mentions without citation

Structure-based mechanism of lipoteichoic acid synthesis by Staphylococcus aureus LtaS.
Lu et al. (2009)
1 more