› 2w7r

X-ray diffraction
1.6Å resolution

Structure of the PDZ domain of Human Microtubule associated serine- threonine kinase 4

Released:
DOI: 10.2210/pdb2w7r/pdb
PDB entry 2w7r coloured by chain, front view.
PDB entry 2w7r coloured by chain, side view.
PDB entry 2w7r coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Unusual binding interactions in PDZ domain crystal structures help explain binding mechanisms.
Elkins JM, Gileadi C, Shrestha L, Phillips C, Wang J, Muniz JR, Doyle DA
Protein Sci 19 731-41 (2010)
PMID: 20120020

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-127266 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Microtubule-associated serine/threonine-protein kinase 4 Chains: A, B
Molecule details ›
Chains: A, B
Length: 98 amino acids
Theoretical weight: 10.65 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O15021 (Residues: 1140-1231; Coverage: 4%)
Gene names: KIAA0303, MAST4
Sequence domains: PDZ domain
Structure domains: Pdz3 Domain

Ligands and Environments

1 bound ligand:
Ligand PO4 1 x PO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: R3
Unit cell:
a: 100.94Å b: 100.94Å c: 69.47Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.196 0.194 0.224
Expression system: Escherichia coli BL21(DE3)

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Citations

5 review citations

Drug-induced secretory diarrhea: A role for CFTR.
Moon et al. (2015)
4 more

2 mentions without citation

Unusual binding interactions in PDZ domain crystal structures help explain binding mechanisms.
Elkins et al. (2010)
1 more