› 2wb8

X-ray diffraction
2.15Å resolution

Crystal structure of Haspin kinase

Released:
DOI: 10.2210/pdb2wb8/pdb
PDB entry 2wb8 coloured by chain, front view.
PDB entry 2wb8 coloured by chain, side view.
PDB entry 2wb8 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of the catalytic domain of Haspin, an atypical kinase implicated in chromatin organization.
Villa F, Capasso P, Tortorici M, Forneris F, de Marco A, Mattevi A, Musacchio A
Proc Natl Acad Sci U S A 106 20204-9 (2009)
PMID: 19918049

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-186268 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Serine/threonine-protein kinase haspin Chain: A
Molecule details ›
Chain: A
Length: 352 amino acids
Theoretical weight: 39.96 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q8TF76 (Residues: 447-798; Coverage: 44%)
Gene names: GSG2, HASPIN
Sequence domains: Haspin like kinase domain
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-1
Spacegroup: P212121
Unit cell:
a: 54.935Å b: 77.71Å c: 82.386Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.23 0.207 0.267
Expression system: Escherichia coli BL21

Quick links

Citations

7 review citations

Pseudokinases-remnants of evolution or key allosteric regulators?
Zeqiraj et al. (2010)
6 more

2 mentions without citation

The Ins and Outs of Aurora B Inner Centromere Localization.
Hindriksen et al. (2017)
1 more