› 2wbx

X-ray diffraction
1.5Å resolution

Crystal structure of mouse cadherin-23 EC1

Released:
DOI: 10.2210/pdb2wbx/pdb
PDB entry 2wbx coloured by chain, front view.
PDB entry 2wbx coloured by chain, side view.
PDB entry 2wbx coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Structural determinants of cadherin-23 function in hearing and deafness.
Sotomayor M, Weihofen WA, Gaudet R, Corey DP
Neuron 66 85-100 (2010)
PMID: 20399731

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-189374 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cadherin-23 Chain: A
Molecule details ›
Chain: A
Length: 102 amino acids
Theoretical weight: 11.55 KDa
Source organism: Mus musculus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q99PF4 (Residues: 24-124; Coverage: 3%)
Gene name: Cdh23
Sequence domains: Cadherin domain
Structure domains: Cadherins

Ligands and Environments

1 bound ligand:
Ligand CA 1 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-E
Spacegroup: C2
Unit cell:
a: 45.891Å b: 49.54Å c: 45.883Å
α: 90° β: 98.97° γ: 90°
R-values:
R R work R free
0.173 0.172 0.199
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

24 review citations

Thinking outside the cell: how cadherins drive adhesion.
Brasch et al. (2012)
23 more

1 mention without citation

Structural determinants of cadherin-23 function in hearing and deafness.
Sotomayor et al. (2010)