› 2wfo

X-ray diffraction
1.73Å resolution

Crystal structure of Machupo virus envelope glycoprotein GP1

Released:
DOI: 10.2210/pdb2wfo/pdb
PDB entry 2wfo coloured by chain, front view.
PDB entry 2wfo coloured by chain, side view.
PDB entry 2wfo coloured by chain, top view.
Source organism: Machupo mammarenavirus
Primary publication:
Unusual molecular architecture of the machupo virus attachment glycoprotein.
Bowden TA, Crispin M, Graham SC, Harvey DJ, Grimes JM, Jones EY, Stuart DI
J Virol 83 8259-65 (2009)
PMID: 19494008

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
Sequence domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-180215 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Glycoprotein 1 Chain: A
Molecule details ›
Chain: A
Length: 182 amino acids
Theoretical weight: 21.05 KDa
Source organism: Machupo mammarenavirus
Expression system: Homo sapiens
UniProt:
  • Canonical: Q6PXS3 (Residues: 87-257; Coverage: 67%)
Gene name: GP1
Sequence domains: Arenavirus glycoprotein

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
1 bound ligand:
Ligand NAG 3 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-1
Spacegroup: P212121
Unit cell:
a: 51.523Å b: 55.07Å c: 61.327Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.174 0.172 0.213
Expression system: Homo sapiens

Quick links

Citations

12 review citations

The curious case of arenavirus entry, and its inhibition.
Nunberg et al. (2012)
11 more

16 mentions without citation

Cells under siege: viral glycoprotein interactions at the cell surface.
Bowden et al. (2011)
15 more