› 2wft

X-ray diffraction
2.8Å resolution

Crystal structure of the human HIP ectodomain

Released:
DOI: 10.2210/pdb2wft/pdb
PDB entry 2wft coloured by chain, front view.
PDB entry 2wft coloured by chain, side view.
PDB entry 2wft coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural insights into hedgehog ligand sequestration by the human hedgehog-interacting protein HHIP.
Bishop B, Aricescu AR, Harlos K, O'Callaghan CA, Jones EY, Siebold C
Nat Struct Mol Biol 16 698-703 (2009)
PMID: 19561611

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-188709 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Hedgehog-interacting protein Chains: A, B
Molecule details ›
Chains: A, B
Length: 458 amino acids
Theoretical weight: 51.13 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q96QV1 (Residues: 214-671; Coverage: 67%)
Gene names: HHIP, HIP, UNQ5825/PRO19644
Sequence domains:
Structure domains: Laminin

Ligands and Environments

2 bound ligands:
Ligand NA 3 x NA
Ligand CL 3 x CL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID29
Spacegroup: P3121
Unit cell:
a: 100.976Å b: 100.976Å c: 305.916Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.201 0.199 0.238
Expression system: Homo sapiens

Quick links

Citations

23 review citations

Mechanisms and functions of Hedgehog signalling across the metazoa.
Ingham et al. (2011)
22 more

3 mentions without citation

Structural insights into hedgehog ligand sequestration by the human hedgehog-interacting protein HHIP.
Bishop et al. (2009)
2 more