› 2whv

X-ray diffraction
2.36Å resolution

CRYSTAL STRUCTURE OF MOUSE CADHERIN-23 EC1-2 (ALL CATION BINDING SITES OCCUPIED BY CALCIUM)

Released:
DOI: 10.2210/pdb2whv/pdb
PDB entry 2whv coloured by chain, front view.
PDB entry 2whv coloured by chain, side view.
PDB entry 2whv coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Structural determinants of cadherin-23 function in hearing and deafness.
Sotomayor M, Weihofen WA, Gaudet R, Corey DP
Neuron 66 85-100 (2010)
PMID: 20399731

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-189374 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cadherin-23 Chain: A
Molecule details ›
Chain: A
Length: 214 amino acids
Theoretical weight: 23.86 KDa
Source organism: Mus musculus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q99PF4 (Residues: 24-228; Coverage: 6%)
Gene name: Cdh23
Sequence domains: Cadherin domain
Structure domains: Cadherins

Ligands and Environments

4 bound ligands:
Ligand CA 4 x CA
Ligand K 4 x K
Ligand CL 1 x CL
Ligand GOL 1 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007
Spacegroup: R32
Unit cell:
a: 151.29Å b: 151.29Å c: 136.881Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.201 0.2 0.221
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

23 review citations

Cadherins in brain morphogenesis and wiring.
Hirano et al. (2012)
22 more

7 mentions without citation

Thinking outside the cell: how cadherins drive adhesion.
Brasch et al. (2012)
6 more