› 2wl7

X-ray diffraction
2.03Å resolution

Crystal structure of the PSD93 PDZ1 domain

Released:
DOI: 10.2210/pdb2wl7/pdb
PDB entry 2wl7 coloured by chain, front view.
PDB entry 2wl7 coloured by chain, side view.
PDB entry 2wl7 coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Structure of the first PDZ domain of human PSD-93.
Fiorentini M, Nielsen AK, Kristensen O, Kastrup JS, Gajhede M
Acta Crystallogr Sect F Struct Biol Cryst Commun 65 1254-7 (2009)
PMID: 20054121

Function and Biology Details

Reaction catalysed: 
ATP + GMP = ADP + GDP
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-187592 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Disks large homolog 2 Chain: A
Molecule details ›
Chain: A
Length: 102 amino acids
Theoretical weight: 10.95 KDa
Source organism: Mus musculus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q91XM9 (Residues: 93-188; Coverage: 11%)
Gene names: Dlg2, Dlgh2
Sequence domains: PDZ domain
Structure domains: Pdz3 Domain

Ligands and Environments

2 bound ligands:
Ligand SO4 3 x SO4
Ligand CL 1 x CL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU200
Spacegroup: R3
Unit cell:
a: 85.198Å b: 85.198Å c: 45.515Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.169 0.164 0.208
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

2 review citations

PDZ Domains as Drug Targets.
Christensen et al. (2019)
1 more

3 mentions without citation

The multiple-specificity landscape of modular peptide recognition domains.
Gfeller et al. (2011)
2 more