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› 2woz

X-ray diffraction
2Å resolution

The novel beta-propeller of the BTB-Kelch protein Krp1 provides the binding site for Lasp-1 that is necessary for pseudopodia extension

Released:
DOI: 10.2210/pdb2woz/pdb
Model geometry
Fit model/data
PDB entry 2woz coloured by chain, front view.
PDB entry 2woz coloured by chain, side view.
PDB entry 2woz coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
Novel beta-propeller of the BTB-Kelch protein Krp1 provides a binding site for Lasp-1 that is necessary for pseudopodial extension.
Gray CH, McGarry LC, Spence HJ, Riboldi-Tunnicliffe A, Ozanne BW
J Biol Chem 284 30498-507 (2009)
PMID: 19726686

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-190169 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Kelch-like protein 41 Chain: A
Molecule details ›
Chain: A
Length: 318 amino acids
Theoretical weight: 35.42 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9ER30 (Residues: 289-606; Coverage: 53%)
Gene names: Kbtbd10, Klhl41, Krp1
Sequence domains: Kelch motif
Structure domains: Kelch-type beta propeller

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: ESRF BEAMLINE ID29
Spacegroup: P21212
Unit cell:
a: 66.11Å b: 98.53Å c: 46.97Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.237 0.237 0.279
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

6 review citations

Structural basis of Keap1 interactions with Nrf2.
Canning et al. (2015)
5 more

9 mentions without citation

Kelch proteins: emerging roles in skeletal muscle development and diseases.
Gupta et al. (2014)
8 more