› 2wq5

X-ray diffraction
1.65Å resolution

Non-antibiotic properties of tetracyclines: structural basis for inhibition of secretory phospholipase A2.

Released:
DOI: 10.2210/pdb2wq5/pdb
PDB entry 2wq5 coloured by chain, front view.
PDB entry 2wq5 coloured by chain, side view.
PDB entry 2wq5 coloured by chain, top view.
Source organism: Naja naja
Primary publication:
Nonantibiotic properties of tetracyclines: structural basis for inhibition of secretory phospholipase A2.
Dalm D, Palm GJ, Aleksandrov A, Simonson T, Hinrichs W
J Mol Biol 398 83-96 (2010)
PMID: 20211188

Function and Biology Details

Reaction catalysed: 
Phosphatidylcholine + H(2)O = 1-acylglycerophosphocholine + a carboxylate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-147368 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Acidic phospholipase A2 2 Chain: A
Molecule details ›
Chain: A
Length: 119 amino acids
Theoretical weight: 13.36 KDa
Source organism: Naja naja
UniProt:
  • Canonical: P15445 (Residues: 1-119; Coverage: 100%)
Sequence domains: Phospholipase A2
Structure domains: Phospholipase A2 domain

Ligands and Environments

3 bound ligands:
Ligand CA 1 x CA
Ligand SO4 1 x SO4
Ligand MIY 1 x MIY
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007
Spacegroup: P213
Unit cell:
a: 68.712Å b: 68.712Å c: 68.712Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.191 0.189 0.23

Quick links

Citations

5 review citations

Doxycycline as an anti-inflammatory agent: updates in dermatology.
Henehan et al. (2017)
4 more

1 mention without citation

Proteomic Investigations of Two Pakistani Naja Snake Venoms Species Unravel the Venom Complexity, Posttranslational Modifications, and Presence of Extracellular Vesicles.
Manuwar et al. (2020)