› 2wr0

X-ray diffraction
2.45Å resolution

Structures of influenza H2 Hemagglutinins

Released:
DOI: 10.2210/pdb2wr0/pdb
Model geometry
Fit model/data
PDB entry 2wr0 coloured by chain, front view.
PDB entry 2wr0 coloured by chain, side view.
PDB entry 2wr0 coloured by chain, top view.
Source organism: unidentified influenza virus
Primary publication:
Structures of receptor complexes formed by hemagglutinins from the Asian Influenza pandemic of 1957.
Liu J, Stevens DJ, Haire LF, Walker PA, Coombs PJ, Russell RJ, Gamblin SJ, Skehel JJ
Proc Natl Acad Sci U S A 106 17175-80 (2009)
PMID: 19805083

Function and Biology Details

Reaction catalysed: 
N-acetyl-O-acetylneuraminate + H(2)O = N-acetylneuraminate + acetate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-112060 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (4 distinct):
Hemagglutinin-esterase-fusion glycoprotein Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 509 amino acids
Theoretical weight: 57.59 KDa
Source organism: unidentified influenza virus
UniProt:
  • Canonical: D0VWP8 (Residues: 1-509; Coverage: 100%)
Gene name: HE
Sequence domains: Haemagglutinin
Structure domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, BMA
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, BMA, MAN
Carbohydrate polymer
1 bound ligand:
Ligand NAG 3 x NAG
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: DIAMOND BEAMLINE I02
Spacegroup: P212121
Unit cell:
a: 68.271Å b: 140.522Å c: 198.891Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.215 0.213 0.256

Quick links

Citations

32 review citations

Influenza A viruses: new research developments.
Medina et al. (2011)
31 more

6 mentions without citation

Structures of receptor complexes formed by hemagglutinins from the Asian Influenza pandemic of 1957.
Liu et al. (2009)
5 more