› 2wsw

X-ray diffraction
2.29Å resolution

Crystal Structure of Carnitine Transporter from Proteus mirabilis

Released:
DOI: 10.2210/pdb2wsw/pdb
PDB entry 2wsw coloured by chain, front view.
PDB entry 2wsw coloured by chain, side view.
PDB entry 2wsw coloured by chain, top view.
Source organism: Proteus mirabilis
Primary publication:
Structural basis of Na(+)-independent and cooperative substrate/product antiport in CaiT.
Schulze S, Köster S, Geldmacher U, Terwisscha van Scheltinga AC, Kühlbrandt W
Nature 467 233-6 (2010)
PMID: 20829798

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-110075 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
L-carnitine/gamma-butyrobetaine antiporter Chain: A
Molecule details ›
Chain: A
Length: 509 amino acids
Theoretical weight: 56.81 KDa
Source organism: Proteus mirabilis
UniProt:
  • Canonical: B4EY22 (Residues: 3-504; Coverage: 98%)
Gene names: PMI2654, caiT
Sequence domains: BCCT, betaine/carnitine/choline family transporter

Ligands and Environments

3 bound ligands:
Ligand GOL 1 x GOL
Ligand CM5 1 x CM5
Ligand 1PE 1 x 1PE
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: R3
Unit cell:
a: 129.198Å b: 129.198Å c: 160.264Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.21 0.209 0.234

Quick links

Citations

15 review citations

SLC6 neurotransmitter transporters: structure, function, and regulation.
Kristensen et al. (2011)
14 more

8 mentions without citation

Conservation of complex knotting and slipknotting patterns in proteins.
Sułkowska et al. (2012)
7 more