› 2wx4

X-ray diffraction
2.8Å resolution

Asymmetric trimer of the Drosophila melanogaster DCP1 C-terminal domain

Released:
DOI: 10.2210/pdb2wx4/pdb
PDB entry 2wx4 coloured by chain, front view.
PDB entry 2wx4 coloured by chain, side view.
PDB entry 2wx4 coloured by chain, top view.
Source organism: Drosophila melanogaster
Primary publication:
DCP1 forms asymmetric trimers to assemble into active mRNA decapping complexes in metazoa.
Tritschler F, Braun JE, Motz C, Igreja C, Haas G, Truffault V, Izaurralde E, Weichenrieder O
Proc Natl Acad Sci U S A 106 21591-6 (2009)
PMID: 19966221

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-194333 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
mRNA-decapping enzyme C-terminal domain-containing protein Chains: A, B, C, D, E, F
Molecule details ›
Chains: A, B, C, D, E, F
Length: 46 amino acids
Theoretical weight: 5.22 KDa
Source organism: Drosophila melanogaster
Expression system: Escherichia coli K-12
UniProt:
  • Canonical: Q9W1H5 (Residues: 328-366; Coverage: 11%)
Gene names: CG11183, DCP1, Dcp-1, Dcp1, Dcp1p, Dmel\CG11183, Dmel_CG11183, anon-WO0118547.163, dDCP1, dDcp1, dcp-1
Sequence domains: mRNA-decapping enzyme C-terminus
Structure domains: Helix Hairpins

Ligands and Environments

1 bound ligand:
Ligand SO4 5 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: P6122
Unit cell:
a: 120.92Å b: 120.92Å c: 134.47Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.217 0.215 0.267
Expression system: Escherichia coli K-12

Quick links

Citations

11 review citations

RNA granules: the good, the bad and the ugly.
Thomas et al. (2011)
10 more

1 mention without citation

DCP1 forms asymmetric trimers to assemble into active mRNA decapping complexes in metazoa.
Tritschler et al. (2009)