Function and Biology Details
Reactions catalysed:
S-adenosyl-L-methionine + a 5'-(5'-triphosphoguanosine)-[mRNA] = S-adenosyl-L-homocysteine + a 5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA]
S-adenosyl-L-methionine + a 5'-(N(7)-methyl 5'-triphosphoguanosine)-(ribonucleotide)-[mRNA] = S-adenosyl-L-homocysteine + a 5'-(N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-ribonucleotide)-[mRNA]
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1)
Selective hydrolysis of -Xaa-Xaa-|-Yaa- bonds in which each of the Xaa can be either Arg or Lys and Yaa can be either Ser or Ala.
NTP + H(2)O = NDP + phosphate
ATP + H(2)O = ADP + phosphate
Sequence domains:
- P-loop containing nucleoside triphosphate hydrolase
- Helicase superfamily 1/2, ATP-binding domain
- Non-structural protein NS3, peptidase S7, flavivirus
- Helicase, C-terminal domain-like
- Non-structural protein NS3-like, DEAD box helicase, flavivirus
- Peptidase S1, PA clan
- Peptidase S1, PA clan, chymotrypsin-like fold
Structure analysis Details
Assembly composition:
hetero dimer (preferred)
Assembly name:
Serine protease NS3 (preferred)
PDBe Complex ID:
PDB-CPX-174140 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Serine protease NS3
Molecule details ›
Chain: A
Length: 619 amino acids
Theoretical weight: 69.58 KDa
Source organism: Dengue virus
Expression system: Escherichia coli
UniProt:
Length: 619 amino acids
Theoretical weight: 69.58 KDa
Source organism: Dengue virus
Expression system: Escherichia coli
UniProt:
- Canonical:
Q2YHF0 (Residues: 1475-1647, 1648-2092; Coverage: 18%)
- Peptidase S7, Flavivirus NS3 serine protease
- Flavivirus DEAD domain
- Flavivirus NS3 helicase, C-terminal helical domain
Serine protease subunit NS2B
Molecule details ›
Chain: C
Length: 31 amino acids
Theoretical weight: 2.9 KDa
Source organism: Dengue virus
Expression system: Escherichia coli
UniProt:
Length: 31 amino acids
Theoretical weight: 2.9 KDa
Source organism: Dengue virus
Expression system: Escherichia coli
UniProt:
- Canonical: Q2YHF0 (Residues: 1393-1410; Coverage: 1%)
