Function and Biology Details
Reaction catalysed:
Cleavage of Leu-|- bond in angiotensinogen to generate angiotensin I.
Biochemical function:
Biological process:
Cellular component:
Structure analysis Details
Assembly composition:
hetero dimer (preferred)
Assembly name:
Renin and Angiotensin-1 (preferred)
PDBe Complex ID:
PDB-CPX-133567 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Renin
Molecule details ›
Chains: A, C, E, G
Length: 383 amino acids
Theoretical weight: 42.36 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
Sequence domains:
Length: 383 amino acids
Theoretical weight: 42.36 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
- Canonical:
P00797 (Residues: 24-406; Coverage: 100%)
Sequence domains:
Angiotensinogen
Molecule details ›
Chains: B, D, F, H
Length: 452 amino acids
Theoretical weight: 49.81 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
Sequence domains: Serpin (serine protease inhibitor)
Length: 452 amino acids
Theoretical weight: 49.81 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
- Canonical: P01019 (Residues: 25-476; Coverage: 100%)
Sequence domains: Serpin (serine protease inhibitor)
Ligands and Environments
No bound ligands
No modified residues
Experiments and Validation Details
wwPDB Validation report is not available for this entry.
X-ray source:
DIAMOND BEAMLINE I03
Spacegroup:
R3
Expression system: Escherichia coli BL21(DE3)
