Function and Biology Details
Reaction catalysed:
ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate
Biochemical function:
Biological process:
Cellular component:
- not assigned
Sequence domains:
- Phosphatidylinositol 3-/4-kinase, catalytic domain
- Phosphoinositide 3-kinase, accessory (PIK) domain
- Phosphatidylinositol 3/4-kinase, conserved site
- Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily
- Protein kinase-like domain superfamily
- Phosphoinositide 3-kinase, accessory (PIK) domain superfamily
- Armadillo-type fold
- Phosphatidylinositol kinase
1 more domain
Structure analysis Details
Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-194334 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Phosphatidylinositol 3-kinase catalytic subunit type 3
Molecule details ›
Chains: A, B
Length: 696 amino acids
Theoretical weight: 78.77 KDa
Source organism: Drosophila melanogaster
Expression system: Escherichia coli BL21(DE3)
UniProt:
Sequence domains:
Length: 696 amino acids
Theoretical weight: 78.77 KDa
Source organism: Drosophila melanogaster
Expression system: Escherichia coli BL21(DE3)
UniProt:
- Canonical:
Q9W1M7 (Residues: 258-949; Coverage: 73%)
Sequence domains:
- Phosphoinositide 3-kinase family, accessory domain (PIK domain)
- Phosphatidylinositol 3- and 4-kinase
Ligands and Environments
No bound ligands
No modified residues
Experiments and Validation Details
X-ray source:
ESRF BEAMLINE ID14-4
Spacegroup:
I212121
Expression system: Escherichia coli BL21(DE3)
