› 2x7h

X-ray diffraction
1.6Å resolution

Crystal structure of the human MGC45594 gene product in complex with fenoprofen

Released:
DOI: 10.2210/pdb2x7h/pdb
PDB entry 2x7h coloured by chain, front view.
PDB entry 2x7h coloured by chain, side view.
PDB entry 2x7h coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Shafqat N, Yue WW, Ugochukwu E, Niesen F, Vollmar M, Chaikuad A, Pike ACW, von Delft F, Smee C, Arrowsmith C, Weigelt J, Edwards A, Bountra C, Oppermann U

Function and Biology Details

Reaction catalysed: 
11-alpha-hydroxy-9,15-dioxoprost-5-enoate + NAD(P)(+) = (5Z)-(13E)-11-alpha-hydroxy-9,15-dioxoprosta-5,13-dienoate + NAD(P)H
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-185392 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Prostaglandin reductase 3 Chains: A, B
Molecule details ›
Chains: A, B
Length: 370 amino acids
Theoretical weight: 39.48 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q8N4Q0 (Residues: 25-371; Coverage: 92%)
Gene names: PTGR3, ZADH2
Sequence domains:
Structure domains:

Ligands and Environments


Cofactor: Ligand NAP 2 x NAP
2 bound ligands:
Ligand PFN 6 x PFN
Ligand EDO 13 x EDO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I03
Spacegroup: P1
Unit cell:
a: 46.6Å b: 52.05Å c: 75.73Å
α: 94.28° β: 91.29° γ: 102.18°
R-values:
R R work R free
0.168 0.168 0.194
Expression system: Escherichia coli BL21(DE3)

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