› 2x7r

X-ray diffraction
2Å resolution

Crystal structure of a late fusion intermediate of HIV-1 gp41

Released:
DOI: 10.2210/pdb2x7r/pdb
PDB entry 2x7r coloured by chain, front view.
PDB entry 2x7r coloured by chain, side view.
PDB entry 2x7r coloured by chain, top view.
Source organism: Human immunodeficiency virus type 1 lw12.3 isolate
Primary publication:
Crystal structure of HIV-1 gp41 including both fusion peptide and membrane proximal external regions.
Buzon V, Natrajan G, Schibli D, Campelo F, Kozlov MM, Weissenhorn W
PLoS Pathog 6 e1000880 (2010)
PMID: 20463810

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-180641 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Transmembrane protein gp41 Chains: A, D, N
Molecule details ›
Chains: A, D, N
Length: 62 amino acids
Theoretical weight: 6.84 KDa
Source organism: Human immunodeficiency virus type 1 lw12.3 isolate
Expression system: Escherichia coli
UniProt:
  • Canonical: Q70626 (Residues: 528-581; Coverage: 7%)
Gene name: env
Transmembrane protein gp41 Chains: B, C, E
Molecule details ›
Chains: B, C, E
Length: 63 amino acids
Theoretical weight: 7.83 KDa
Source organism: Human immunodeficiency virus type 1 lw12.3 isolate
Expression system: Escherichia coli
UniProt:
  • Canonical: Q70626 (Residues: 629-683; Coverage: 7%)
Gene name: env
Structure domains: Helix Hairpins

Ligands and Environments

2 bound ligands:
Ligand NA 3 x NA
Ligand CL 1 x CL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-4
Spacegroup: P63
Unit cell:
a: 57.422Å b: 57.422Å c: 182.768Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.179 0.177 0.214
Expression system: Escherichia coli

Quick links

Citations

27 review citations

Human antibodies that neutralize HIV-1: identification, structures, and B cell ontogenies.
Kwong et al. (2012)
26 more

29 mentions without citation

Approved Antiviral Drugs over the Past 50 Years.
De Clercq et al. (2016)
28 more