› 2x9e

X-ray diffraction
3.1Å resolution

Function and Biology Details

Reaction catalysed: 
ATP + L-seryl/L-threonyl/L-tyrosyl-[protein] = ADP + O-phospho-L-seryl/O-phospho-L-threonyl/O-phospho-L-tyrosyl-[protein]
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-152668 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Dual specificity protein kinase TTK Chain: A
Molecule details ›
Chain: A
Length: 317 amino acids
Theoretical weight: 36.24 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: P33981 (Residues: 514-828; Coverage: 37%)
Gene names: MPS1, MPS1L1, TTK
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand SVE 1 x SVE
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-1
Spacegroup: C2221
Unit cell:
a: 105.665Å b: 113.362Å c: 72.485Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.215 0.215 0.306
Expression system: Trichoplusia ni

Quick links

Citations

19 review citations

Targeting Mitosis in Cancer: Emerging Strategies.
Dominguez-Brauer et al. (2015)
18 more

3 mentions without citation

The MPS1 family of protein kinases.
Liu et al. (2012)
2 more