› 2xc2

X-ray diffraction
1.56Å resolution

Crystal structure of oxidized Schistosoma mansoni Thioredoxin pre- protein at 1.6 Angstrom

Released:
DOI: 10.2210/pdb2xc2/pdb
Model geometry
Fit model/data
PDB entry 2xc2 coloured by chain, front view.
PDB entry 2xc2 coloured by chain, side view.
PDB entry 2xc2 coloured by chain, top view.
Source organism: Schistosoma mansoni
Primary publication:
Structural and functional characterization of Schistosoma mansoni Thioredoxin.
Boumis G, Angelucci F, Bellelli A, Brunori M, Dimastrogiovanni D, Miele AE
Protein Sci 20 1069-76 (2011)
PMID: 21465612

Function and Biology Details

Reaction catalysed: 
Protein dithiol + NAD(P)(+) = protein disulfide + NAD(P)H
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-186151 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Thioredoxin domain-containing protein Chain: A
Molecule details ›
Chain: A
Length: 117 amino acids
Theoretical weight: 13.1 KDa
Source organism: Schistosoma mansoni
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q8T9N5 (Residues: 1-106; Coverage: 100%)
Sequence domains: Thioredoxin
Structure domains: Glutaredoxin

Ligands and Environments

2 bound ligands:
Ligand CA 1 x CA
Ligand ZN 1 x ZN
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: ELETTRA BEAMLINE 5.2R
Spacegroup: P212121
Unit cell:
a: 33.931Å b: 51.998Å c: 59.313Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.207 0.205 0.245
Expression system: Escherichia coli BL21(DE3)

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Citations

5 review citations

Thioredoxin glutathione reductase-dependent redox networks in platyhelminth parasites.
Williams et al. (2013)
4 more

3 mentions without citation

Structural and functional characterization of Schistosoma mansoni Thioredoxin.
Boumis et al. (2011)
2 more