› 2xr9

X-ray diffraction
2.05Å resolution

Function and Biology Details

Reaction catalysed: 
1-alkyl-sn-glycero-3-phosphoethanolamine + H(2)O = 1-alkyl-sn-glycerol 3-phosphate + ethanolamine
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-179148 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 Chain: A
Molecule details ›
Chain: A
Length: 827 amino acids
Theoretical weight: 95.05 KDa
Source organism: Rattus norvegicus
Expression system: Homo sapiens
UniProt:
  • Canonical: Q64610 (Residues: 36-887; Coverage: 96%)
Gene names: Atx, Enpp2, Npps2
Sequence domains:
Structure domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA
Carbohydrate polymer
5 bound ligands:
Ligand SCN 4 x SCN
Ligand ZN 2 x ZN
Ligand CA 1 x CA
Ligand PO4 1 x PO4
Ligand IOD 28 x IOD
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-D
Spacegroup: P1
Unit cell:
a: 53.808Å b: 63.289Å c: 70.471Å
α: 98.78° β: 106.22° γ: 99.77°
R-values:
R R work R free
0.175 0.173 0.221
Expression system: Homo sapiens

Quick links

Citations

49 review citations

Phospholipase D: enzymology, functionality, and chemical modulation.
Selvy et al. (2011)
48 more

11 mentions without citation

Cellular function and molecular structure of ecto-nucleotidases.
Zimmermann et al. (2012)
10 more