› 2xsm

X-ray diffraction
5.5Å resolution

Crystal structure of the mammalian cytosolic chaperonin CCT in complex with tubulin

Released:
DOI: 10.2210/pdb2xsm/pdb
PDB entry 2xsm coloured by chain, front view.
PDB entry 2xsm coloured by chain, side view.
PDB entry 2xsm coloured by chain, top view.
Source organism: Bos taurus
Primary publication:
Crystal structure of the open conformation of the mammalian chaperonin CCT in complex with tubulin.
Muñoz IG, Yébenes H, Zhou M, Mesa P, Serna M, Park AY, Bragado-Nilsson E, Beloso A, de Cárcer G, Malumbres M, Robinson CV, Valpuesta JM, Montoya G
Nat Struct Mol Biol 18 14-9 (2011)
PMID: 21151115

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero hexadecamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-163331 (preferred)
Entry contents:
15 distinct polypeptide molecules
Macromolecules (15 distinct):
CCT Chain: A
Molecule details ›
Chain: A
Length: 489 amino acids
Theoretical weight: 41.63 KDa
Source organism: Bos taurus
CCT Chain: B
Molecule details ›
Chain: B
Length: 478 amino acids
Theoretical weight: 40.7 KDa
Source organism: Bos taurus
CCT Chain: C
Molecule details ›
Chain: C
Length: 455 amino acids
Theoretical weight: 38.74 KDa
Source organism: Bos taurus
CCT Chain: D
Molecule details ›
Chain: D
Length: 471 amino acids
Theoretical weight: 40.1 KDa
Source organism: Bos taurus
CCT Chain: E
Molecule details ›
Chain: E
Length: 472 amino acids
Theoretical weight: 40.19 KDa
Source organism: Bos taurus
CCT Chain: F
Molecule details ›
Chain: F
Length: 466 amino acids
Theoretical weight: 39.68 KDa
Source organism: Bos taurus
CCT Chain: G
Molecule details ›
Chain: G
Length: 485 amino acids
Theoretical weight: 41.29 KDa
Source organism: Bos taurus
CCT Chain: H
Molecule details ›
Chain: H
Length: 474 amino acids
Theoretical weight: 40.36 KDa
Source organism: Bos taurus
CCT Chain: I
Molecule details ›
Chain: I
Length: 293 amino acids
Theoretical weight: 24.95 KDa
Source organism: Bos taurus
CCT Chain: J
Molecule details ›
Chain: J
Length: 299 amino acids
Theoretical weight: 25.46 KDa
Source organism: Bos taurus
CCT Chain: K
Molecule details ›
Chain: K
Length: 394 amino acids
Theoretical weight: 33.55 KDa
Source organism: Bos taurus
CCT Chains: L, O
Molecule details ›
Chains: L, O
Length: 297 amino acids
Theoretical weight: 25.29 KDa
Source organism: Bos taurus
CCT Chain: M
Molecule details ›
Chain: M
Length: 298 amino acids
Theoretical weight: 25.38 KDa
Source organism: Bos taurus
CCT Chain: N
Molecule details ›
Chain: N
Length: 289 amino acids
Theoretical weight: 24.61 KDa
Source organism: Bos taurus
CCT Chain: P
Molecule details ›
Chain: P
Length: 481 amino acids
Theoretical weight: 40.95 KDa
Source organism: Bos taurus

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06SA
Spacegroup: P21212
Unit cell:
a: 272.7Å b: 313.5Å c: 158.3Å
α: 90° β: 90° γ: 90°

Quick links

Citations

16 review citations

Molecular chaperones in protein folding and proteostasis.
Hartl et al. (2011)
15 more

9 mentions without citation

Contribution of the Type II Chaperonin, TRiC/CCT, to Oncogenesis.
Roh et al. (2015)
8 more