› 2xxl

X-ray diffraction
1.8Å resolution

Crystal structure of drosophila Grass clip serine protease of Toll pathway

Released:
DOI: 10.2210/pdb2xxl/pdb
PDB entry 2xxl coloured by chain, front view.
PDB entry 2xxl coloured by chain, side view.
PDB entry 2xxl coloured by chain, top view.
Source organism: Drosophila melanogaster
Primary publication:
Structure-function analysis of grass clip serine protease involved in Drosophila Toll pathway activation.
Kellenberger C, Leone P, Coquet L, Jouenne T, Reichhart JM, Roussel A
J Biol Chem 286 12300-7 (2011)
PMID: 21310954

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-194210 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Serine protease grass Chains: A, B
Molecule details ›
Chains: A, B
Length: 408 amino acids
Theoretical weight: 45.02 KDa
Source organism: Drosophila melanogaster
Expression system: Drosophila melanogaster
UniProt:
  • Canonical: Q9VB68 (Residues: 1-377; Coverage: 100%)
Gene names: CG5896, c-SP1, grass
Sequence domains:
Structure domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA, FUC
Carbohydrate polymer
2 bound ligands:
Ligand NAG 1 x NAG
Ligand CA 2 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-2
Spacegroup: P212121
Unit cell:
a: 78.26Å b: 92.04Å c: 113.34Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.178 0.177 0.203
Expression system: Drosophila melanogaster

Quick links

Citations

1 review citation

Arthropod Innate Immune Systems and Vector-Borne Diseases.
Baxter et al. (2017)
14 other articles

3 mentions without citation

Clip-domain serine proteases as immune factors in insect hemolymph.
Kanost et al. (2015)
2 more