› 2xxv

X-ray diffraction
1.7Å resolution

Crystal structure of the GluK2 (GluR6) M770K LBD dimer in complex with kainate

Released:
DOI: 10.2210/pdb2xxv/pdb
PDB entry 2xxv coloured by chain, front view.
PDB entry 2xxv coloured by chain, side view.
PDB entry 2xxv coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
Conformational flexibility of the ligand-binding domain dimer in kainate receptor gating and desensitization.
Nayeem N, Mayans O, Green T
J Neurosci 31 2916-24 (2011)
PMID: 21414913

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-154585 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glutamate receptor ionotropic, kainate 2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 261 amino acids
Theoretical weight: 29.62 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P42260 (Residues: 429-544, 667-806; Coverage: 29%)
Gene names: Glur6, Grik2
Sequence domains:
Structure domains: Periplasmic binding protein-like II

Ligands and Environments

2 bound ligands:
Ligand KAI 2 x KAI
Ligand CL 1 x CL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I02
Spacegroup: I222
Unit cell:
a: 96.26Å b: 104.873Å c: 113.589Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.167 0.165 0.204
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

5 review citations

Structure, Function, and Pharmacology of Glutamate Receptor Ion Channels.
Hansen et al. (2021)
4 more

1 mention without citation

Conformational flexibility of the ligand-binding domain dimer in kainate receptor gating and desensitization.
Nayeem et al. (2011)