› 2y6w

X-ray diffraction
2Å resolution

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-187784 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Bcl-2-like protein 2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 177 amino acids
Theoretical weight: 19.51 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q92843 (Residues: 1-164; Coverage: 85%)
Gene names: BCL2L2, BCLW, KIAA0271
Sequence domains:

Ligands and Environments

2 bound ligands:
Ligand PEG 5 x PEG
Ligand PGE 1 x PGE
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06DA
Spacegroup: P43212
Unit cell:
a: 76.227Å b: 76.227Å c: 112.847Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.201 0.199 0.244
Expression system: Escherichia coli BL21

Quick links

Citations

5 review citations

Structural biology of the Bcl-2 family and its mimicry by viral proteins.
Kvansakul et al. (2013)
4 more

7 mentions without citation

The deadly landscape of pro-apoptotic BCL-2 proteins in the outer mitochondrial membrane.
Luna-Vargas et al. (2016)
6 more