› 2y7b

X-ray diffraction
1.9Å resolution

Crystal structure of the PH domain of human Actin-binding protein anillin ANLN

Released:
DOI: 10.2210/pdb2y7b/pdb
PDB entry 2y7b coloured by chain, front view.
PDB entry 2y7b coloured by chain, side view.
PDB entry 2y7b coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Vollmar M, Wang J, Krojer T, Elkins J, Filippakopoulos P, Ugochukwu E, Cocking R, von Delft F, Bountra C, Arrowsmith CH, Weigelt J, Edwards A, Knapp S

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-192518 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Anillin Chain: A
Molecule details ›
Chain: A
Length: 134 amino acids
Theoretical weight: 15.91 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9NQW6 (Residues: 980-1113; Coverage: 12%)
Gene name: ANLN
Sequence domains: PH domain
Structure domains: Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)

Ligands and Environments

1 bound ligand:
Ligand EDO 5 x EDO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I02
Spacegroup: P212121
Unit cell:
a: 34.3Å b: 59.417Å c: 64.717Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.195 0.192 0.262
Expression system: Escherichia coli BL21(DE3)

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