› 2y8d

X-ray diffraction
1.84Å resolution

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-180411 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Erythrocyte membrane protein 1 Chain: A
Molecule details ›
Chain: A
Length: 306 amino acids
Theoretical weight: 36.27 KDa
Source organism: Plasmodium falciparum
Expression system: Escherichia coli
UniProt:
  • Canonical: Q6UDW7 (Residues: 2326-2631; Coverage: 10%)
Gene name: var
Sequence domains: Duffy binding domain
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand DHL 2 x DHL
Ligand BEN 1 x BEN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SOLEIL BEAMLINE PROXIMA 1
Spacegroup: C2
Unit cell:
a: 85.859Å b: 56.229Å c: 75.849Å
α: 90° β: 123.09° γ: 90°
R-values:
R R work R free
0.205 0.203 0.235
Expression system: Escherichia coli

Quick links

Citations

4 review citations

Paths to a malaria vaccine illuminated by parasite genomics.
Conway DJ. (2015)
3 more

5 mentions without citation

Structural basis for placental malaria mediated by Plasmodium falciparum VAR2CSA.
Ma et al. (2021)
4 more