› 2ycw

X-ray diffraction
3Å resolution

TURKEY BETA1 ADRENERGIC RECEPTOR WITH STABILISING MUTATIONS AND BOUND ANTAGONIST CARAZOLOL

Released:
DOI: 10.2210/pdb2ycw/pdb
PDB entry 2ycw coloured by chain, front view.
PDB entry 2ycw coloured by chain, side view.
PDB entry 2ycw coloured by chain, top view.
Source organism: Meleagris gallopavo
Primary publication:
Two distinct conformations of helix 6 observed in antagonist-bound structures of a beta1-adrenergic receptor.
Moukhametzianov R, Warne T, Edwards PC, Serrano-Vega MJ, Leslie AG, Tate CG, Schertler GF
Proc Natl Acad Sci U S A 108 8228-32 (2011)
PMID: 21540331

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-139703 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Beta-1 adrenergic receptor Chains: A, B
Molecule details ›
Chains: A, B
Length: 313 amino acids
Theoretical weight: 35.75 KDa
Source organism: Meleagris gallopavo
Expression system: Trichoplusia ni
UniProt:
  • Canonical: P07700 (Residues: 33-367; Coverage: 63%)
Gene name: ADRB1
Sequence domains: 7 transmembrane receptor (rhodopsin family)
Structure domains: Rhodopsin 7-helix transmembrane proteins

Ligands and Environments

3 bound ligands:
Ligand CAU 2 x CAU
Ligand 2CV 5 x 2CV
Ligand NA 2 x NA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06SA
Spacegroup: P21
Unit cell:
a: 89.398Å b: 57.056Å c: 109.542Å
α: 90° β: 113.52° γ: 90°
R-values:
R R work R free
0.25 0.248 0.295
Expression system: Trichoplusia ni

Quick links

Citations

27 review citations

Molecular signatures of G-protein-coupled receptors.
Venkatakrishnan et al. (2013)
26 more

36 mentions without citation

Structure-function of the G protein-coupled receptor superfamily.
Katritch et al. (2013)
35 more