› 2yd2

X-ray diffraction
2.55Å resolution

Crystal structure of the N-terminal Ig1-2 module of Human Receptor Protein Tyrosine Phosphatase Sigma

Released:
DOI: 10.2210/pdb2yd2/pdb
PDB entry 2yd2 coloured by chain, front view.
PDB entry 2yd2 coloured by chain, side view.
PDB entry 2yd2 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Proteoglycan-specific molecular switch for RPTPσ clustering and neuronal extension.
Coles CH, Shen Y, Tenney AP, Siebold C, Sutton GC, Lu W, Gallagher JT, Jones EY, Flanagan JG, Aricescu AR
Science 332 484-8 (2011)
PMID: 21454754

Function and Biology Details

Reaction catalysed: 
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-171644 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Receptor-type tyrosine-protein phosphatase S Chain: A
Molecule details ›
Chain: A
Length: 214 amino acids
Theoretical weight: 23.71 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q13332 (Residues: 30-244; Coverage: 11%)
Gene name: PTPRS
Sequence domains:
Structure domains: Immunoglobulins

Ligands and Environments

2 bound ligands:
Ligand CL 3 x CL
Ligand IOD 4 x IOD
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-3
Spacegroup: C2
Unit cell:
a: 124.4Å b: 29.49Å c: 61.58Å
α: 90° β: 92.61° γ: 90°
R-values:
R R work R free
0.2 0.196 0.26
Expression system: Homo sapiens

Quick links

Citations

74 review citations

Demystifying heparan sulfate-protein interactions.
Xu et al. (2014)
73 more

1 mention without citation

Predicting glycosaminoglycan surface protein interactions and implications for studying axonal growth.
Griffith et al. (2017)