Function and Biology Details
Reaction catalysed:
Cleaves hyaluronate chains at a beta-D-GlcNAc-(1->4)-beta-D-GlcA bond, ultimately breaking the polysaccharide down to 3-(4-deoxy-beta-D-gluc-4-enuronosyl)-N-acetyl-D-glucosamine
Biochemical function:
Biological process:
Cellular component:
- not assigned
Sequence domains:
Structure domain:
Structure analysis Details
Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-189445 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Major tropism determinant N-terminal domain-containing protein
Molecule details ›
Chain: A
Length: 338 amino acids
Theoretical weight: 36.47 KDa
Source organism: Streptococcus pyogenes serotype M1
Expression system: Escherichia coli
UniProt:
Sequence domains:
Length: 338 amino acids
Theoretical weight: 36.47 KDa
Source organism: Streptococcus pyogenes serotype M1
Expression system: Escherichia coli
UniProt:
- Canonical:
Q9A0M7 (Residues: 1-337; Coverage: 100%)
Sequence domains:
Ligands and Environments
No bound ligands
No modified residues
Experiments and Validation Details
X-ray source:
EMBL/DESY, HAMBURG BEAMLINE X31
Spacegroup:
R32
Expression system: Escherichia coli
