› 2yw3

X-ray diffraction
1.67Å resolution

Crystal Structure Analysis of the 4-hydroxy-2-oxoglutarate aldolase/2-deydro-3-deoxyphosphogluconate aldolase from TTHB1

Released:
DOI: 10.2210/pdb2yw3/pdb
PDB entry 2yw3 coloured by chain, front view.
PDB entry 2yw3 coloured by chain, side view.
PDB entry 2yw3 coloured by chain, top view.
Source organism: Thermus thermophilus HB8
Entry authors: Kawano Y, Hashimoto K, Kamiya N, RIKEN Structural Genomics/Proteomics Initiative (RSGI)

Function and Biology Details

Reaction catalysed: 
2-dehydro-3-deoxy-6-phosphate-D-gluconate = pyruvate + D-glyceraldehyde 3-phosphate
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-176160 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
2-dehydro-3-deoxy-phosphogluconate aldolase Chains: A, B, C, D, E, F
Molecule details ›
Chains: A, B, C, D, E, F
Length: 207 amino acids
Theoretical weight: 21.75 KDa
Source organism: Thermus thermophilus HB8
Expression system: Escherichia coli
UniProt:
  • Canonical: Q53W90 (Residues: 1-207; Coverage: 100%)
Gene name: TTHB072
Sequence domains: KDPG and KHG aldolase
Structure domains: Aldolase class I

Ligands and Environments

1 bound ligand:
Ligand PO4 17 x PO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL45PX
Spacegroup: C2
Unit cell:
a: 125.922Å b: 72.685Å c: 161.312Å
α: 90° β: 91.07° γ: 90°
R-values:
R R work R free
0.185 0.182 0.214
Expression system: Escherichia coli

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