› 2z2t

X-ray diffraction
2.1Å resolution

Crystal structure of the complex between gp41 fragment N36 and fusion inhibitor SC34EK

Released:
DOI: 10.2210/pdb2z2t/pdb
PDB entry 2z2t coloured by chain, front view.
PDB entry 2z2t coloured by chain, side view.
PDB entry 2z2t coloured by chain, top view.
Source organism: Human immunodeficiency virus type 1 lw12.3 isolate
Entry authors: Nakamura S, Ohkubo T, Kobayashi Y

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero hexamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-163374 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Transmembrane protein gp41 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 38 amino acids
Theoretical weight: 4.21 KDa
Source organism: Human immunodeficiency virus type 1 lw12.3 isolate
Expression system: Not provided
UniProt:
  • Canonical: Q70626 (Residues: 546-581; Coverage: 4%)
Gene name: env
Fusion inhibitor peptide SC34EK Chains: D, E, F
Molecule details ›
Chains: D, E, F
Length: 36 amino acids
Theoretical weight: 4.41 KDa
Source organism: Human immunodeficiency virus type 1 lw12.3 isolate
Expression system: Not provided

Ligands and Environments

2 bound ligands:
Ligand ACY 1 x ACY
Ligand SO4 1 x SO4
1 modified residue:
Ligand NLE 3 x NLE

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL38B1
Spacegroup: P3121
Unit cell:
a: 105.014Å b: 105.014Å c: 78.308Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.215 0.213 0.238
Expression system: Not provided

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