› 2z6o

X-ray diffraction
1.6Å resolution

Crystal Structure of the Ufc1, Ufm1 conjugating enzyme 1

Released:
DOI: 10.2210/pdb2z6o/pdb
PDB entry 2z6o coloured by chain, front view.
PDB entry 2z6o coloured by chain, side view.
PDB entry 2z6o coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of Ufc1, the Ufm1-conjugating enzyme.
Mizushima T, Tatsumi K, Ozaki Y, Kawakami T, Suzuki A, Ogasahara K, Komatsu M, Kominami E, Tanaka K, Yamane T
Biochem Biophys Res Commun 362 1079-84 (2007)
PMID: 17825256

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-195198 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ubiquitin-fold modifier-conjugating enzyme 1 Chain: A
Molecule details ›
Chain: A
Length: 172 amino acids
Theoretical weight: 19.9 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9Y3C8 (Residues: 1-167; Coverage: 100%)
Gene names: CGI-126, HSPC155, UFC1
Sequence domains: Ubiquitin-fold modifier-conjugating enzyme 1
Structure domains: Ubiquitin Conjugating Enzyme

Ligands and Environments

1 bound ligand:
Ligand MG 1 x MG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL44XU
Spacegroup: P212121
Unit cell:
a: 41.37Å b: 47.601Å c: 82.34Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.196 0.194 0.221
Expression system: Escherichia coli

Quick links

Citations

7 review citations

Ubiquitin-like protein activation by E1 enzymes: the apex for downstream signalling pathways.
Schulman et al. (2009)
6 more

4 mentions without citation

A non-canonical scaffold-type E3 ligase complex mediates protein UFMylation.
Peter et al. (2022)
3 more