› 2z9s

X-ray diffraction
2.9Å resolution

Crystal Structure Analysis of rat HBP23/Peroxiredoxin I, Cys52Ser mutant

Released:
DOI: 10.2210/pdb2z9s/pdb
PDB entry 2z9s coloured by chain, front view.
PDB entry 2z9s coloured by chain, side view.
PDB entry 2z9s coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
Dimer-oligomer interconversion of wild-type and mutant rat 2-Cys peroxiredoxin: disulfide formation at dimer-dimer interfaces is not essential for decamerization.
Matsumura T, Okamoto K, Iwahara SI, Hori H, Takahashi Y, Nishino T, Abe Y
J Biol Chem 283 284-293 (2008)
PMID: 17974571

Function and Biology Details

Reaction catalysed: 
Thioredoxin + ROOH = thioredoxin disulfide + H(2)O + ROH
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo decamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-179033 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Peroxiredoxin-1 Chains: A, B, C, D, E, F, G, H, I, J
Molecule details ›
Chains: A, B, C, D, E, F, G, H, I, J
Length: 199 amino acids
Theoretical weight: 22.12 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q63716 (Residues: 1-199; Coverage: 100%)
Gene names: Prdx1, Tdpx2
Sequence domains:
Structure domains: Glutaredoxin

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PHOTON FACTORY BEAMLINE BL-5A
Spacegroup: P21
Unit cell:
a: 92.312Å b: 111.637Å c: 120.74Å
α: 90° β: 112.03° γ: 90°
R-values:
R R work R free
0.205 0.205 0.269
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

11 review citations

Typical 2-Cys peroxiredoxins--structures, mechanisms and functions.
Hall et al. (2009)
10 more

7 mentions without citation

Structure-based insights into the catalytic power and conformational dexterity of peroxiredoxins.
Hall et al. (2011)
6 more