› 2zbd

X-ray diffraction
2.4Å resolution

Crystal Structure of the SR Calcium Pump with Bound Aluminium Fluoride, ADP and Calcium

Released:
DOI: 10.2210/pdb2zbd/pdb
PDB entry 2zbd coloured by chain, front view.
PDB entry 2zbd coloured by chain, side view.
PDB entry 2zbd coloured by chain, top view.
Source organism: Oryctolagus cuniculus
Primary publication:
Lumenal gating mechanism revealed in calcium pump crystal structures with phosphate analogues.
Toyoshima C, Nomura H, Tsuda T
Nature 432 361-8 (2004)
PMID: 15448704

Function and Biology Details

Reaction catalysed: 
ATP + H(2)O + Ca(2+)(Side 1) = ADP + phosphate + Ca(2+)(Side 2)
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-137501 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:

Ligands and Environments

5 bound ligands:
Ligand CA 2 x CA
Ligand MG 2 x MG
Ligand ALF 1 x ALF
Ligand ADP 1 x ADP
Ligand PC1 2 x PC1
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL41XU
Spacegroup: C2
Unit cell:
a: 162.9Å b: 75.1Å c: 152.1Å
α: 90° β: 109.3° γ: 90°
R-values:
R R work R free
0.248 0.246 0.271

Quick links

Citations

49 review citations

P-type ATPases.
Palmgren et al. (2011)
48 more

17 mentions without citation

Biological membranes.
Watson H. (2015)
16 more