› 2zgc

X-ray diffraction
1.96Å resolution

Crystal Structure of Active Human Granzyme M

Released:
DOI: 10.2210/pdb2zgc/pdb
PDB entry 2zgc coloured by chain, front view.
PDB entry 2zgc coloured by chain, side view.
PDB entry 2zgc coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis for proteolytic specificity of the human apoptosis-inducing granzyme M.
Wu L, Wang L, Hua G, Liu K, Yang X, Zhai Y, Bartlam M, Sun F, Fan Z
J Immunol 183 421-9 (2009)
PMID: 19542453

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-156291 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Granzyme M Chain: A
Molecule details ›
Chain: A
Length: 240 amino acids
Theoretical weight: 26.13 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P51124 (Residues: 26-257; Coverage: 99%)
Gene names: GZMM, MET1
Sequence domains: Trypsin
Structure domains: Trypsin-like serine proteases

Ligands and Environments

1 bound ligand:
Ligand SO4 4 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: BSRF BEAMLINE 3W1A
Spacegroup: P3121
Unit cell:
a: 74.391Å b: 74.391Å c: 113.199Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.212 0.209 0.257
Expression system: Escherichia coli

Quick links

Citations

1 review citation

Orphan granzymes find a home.
Bovenschen et al. (2010)
15 other articles

3 mentions without citation

Granzyme M: behind enemy lines.
de Poot et al. (2014)
2 more