› 2zgq

X-ray diffraction
1.9Å resolution

Crystal structure of AAL mutant L33A in P1 spacegroup

Released:
DOI: 10.2210/pdb2zgq/pdb
PDB entry 2zgq coloured by chain, front view.
PDB entry 2zgq coloured by chain, side view.
PDB entry 2zgq coloured by chain, top view.
Source organism: Cyclocybe aegerita
Primary publication:
Structural basis for the tumor cell apoptosis-inducing activity of an antitumor lectin from the edible mushroom Agrocybe aegerita.
Yang N, Li DF, Feng L, Xiang Y, Liu W, Sun H, Wang DC
J Mol Biol 387 694-705 (2009)
PMID: 19361423

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-180509 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Anti-tumor lectin Chains: A, B
Molecule details ›
Chains: A, B
Length: 167 amino acids
Theoretical weight: 18.14 KDa
Source organism: Cyclocybe aegerita
Expression system: Escherichia coli
UniProt:
  • Canonical: Q6WY08 (Residues: 1-158; Coverage: 100%)
Sequence domains: Galactoside-binding lectin
Structure domains: Jelly Rolls

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU FR-E+ SUPERBRIGHT
Spacegroup: P1
Unit cell:
a: 41.35Å b: 43.43Å c: 56.42Å
α: 69.83° β: 82.44° γ: 61.8°
R-values:
R R work R free
0.21 0.21 0.242
Expression system: Escherichia coli

Quick links

Citations

7 review citations

Bioactive proteins from mushrooms.
Xu et al. (2011)
6 more

1 mention without citation

Mushroom lectins: specificity, structure and bioactivity relevant to human disease.
Hassan et al. (2015)