› 2znn

X-ray diffraction
2.01Å resolution

Human PPAR alpha ligand binding domain in complex with a synthetic agonist TIPP703

Released:
DOI: 10.2210/pdb2znn/pdb
PDB entry 2znn coloured by chain, front view.
PDB entry 2znn coloured by chain, side view.
PDB entry 2znn coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Adaptability and selectivity of human peroxisome proliferator-activated receptor (PPAR) pan agonists revealed from crystal structures.
Oyama T, Toyota K, Waku T, Hirakawa Y, Nagasawa N, Kasuga JI, Hashimoto Y, Miyachi H, Morikawa K
Acta Crystallogr D Biol Crystallogr 65 786-95 (2009)
PMID: 19622862

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-170552 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Peroxisome proliferator-activated receptor alpha Chain: A
Molecule details ›
Chain: A
Length: 273 amino acids
Theoretical weight: 30.86 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q07869 (Residues: 200-468; Coverage: 58%)
Gene names: NR1C1, PPAR, PPARA
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor

Ligands and Environments

1 bound ligand:
Ligand S44 1 x S44
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL38B1
Spacegroup: P21
Unit cell:
a: 44.37Å b: 61.53Å c: 53.12Å
α: 90° β: 106.29° γ: 90°
R-values:
R R work R free
0.214 0.214 0.253
Expression system: Escherichia coli BL21

Quick links

Citations

6 review citations

Mechanisms Mediating the Regulation of Peroxisomal Fatty Acid Beta-Oxidation by PPARĪ±.
Tahri-Joutey et al. (2021)
5 more

14 mentions without citation

Chemistry, Biological Activities and In Silico Bioprospection of Sterols and Triterpenes from Mexican Columnar Cactaceae.
Salazar et al. (2020)
13 more