› 2znq

X-ray diffraction
2.65Å resolution

Human PPAR delta ligand binding domain in complex with a synthetic agonist TIPP401

Released:
DOI: 10.2210/pdb2znq/pdb
PDB entry 2znq coloured by chain, front view.
PDB entry 2znq coloured by chain, side view.
PDB entry 2znq coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Adaptability and selectivity of human peroxisome proliferator-activated receptor (PPAR) pan agonists revealed from crystal structures.
Oyama T, Toyota K, Waku T, Hirakawa Y, Nagasawa N, Kasuga JI, Hashimoto Y, Miyachi H, Morikawa K
Acta Crystallogr D Biol Crystallogr 65 786-95 (2009)
PMID: 19622862

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assemblies composition:
homo dimer
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-169863 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Peroxisome proliferator-activated receptor delta Chains: A, B
Molecule details ›
Chains: A, B
Length: 276 amino acids
Theoretical weight: 31.53 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q03181 (Residues: 170-441; Coverage: 62%)
Gene names: NR1C2, PPARB, PPARD
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor

Ligands and Environments

2 bound ligands:
Ligand B7G 2 x B7G
Ligand 401 2 x 401
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL38B1
Spacegroup: P21
Unit cell:
a: 39.172Å b: 91.947Å c: 96.361Å
α: 90° β: 98.01° γ: 90°
R-values:
R R work R free
0.214 0.214 0.276
Expression system: Escherichia coli BL21

Quick links

Citations

6 review citations

Mechanisms Mediating the Regulation of Peroxisomal Fatty Acid Beta-Oxidation by PPARĪ±.
Tahri-Joutey et al. (2021)
5 more

6 mentions without citation

Activation of PPARĪ“: from computer modelling to biological effects.
Kahremany et al. (2015)
5 more