› 2zo4

X-ray diffraction
2.1Å resolution

Crystal structure of metallo-beta-lactamase family protein TTHA1429 from Thermus thermophilus HB8

Released:
DOI: 10.2210/pdb2zo4/pdb
PDB entry 2zo4 coloured by chain, front view.
PDB entry 2zo4 coloured by chain, side view.
PDB entry 2zo4 coloured by chain, top view.
Source organism: Thermus thermophilus HB8
Primary publication:
Crystal structure of TTHA1429, a novel metallo-beta-lactamase superfamily protein from Thermus thermophilus HB8.
Yamamura A, Ohtsuka J, Kubota K, Agari Y, Ebihara A, Nakagawa N, Nagata K, Tanokura M
Proteins 73 1053-7 (2008)
PMID: 18767153

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-177957 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Metallo-beta-lactamase domain-containing protein Chain: A
Molecule details ›
Chain: A
Length: 317 amino acids
Theoretical weight: 35.5 KDa
Source organism: Thermus thermophilus HB8
Expression system: Escherichia coli
UniProt:
  • Canonical: Q5SIE5 (Residues: 1-317; Coverage: 100%)
Gene name: TTHA1429
Sequence domains:
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand ZN 2 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL26B2
Spacegroup: P212121
Unit cell:
a: 55.286Å b: 62.885Å c: 87.425Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.201 0.198 0.257
Expression system: Escherichia coli

Quick links

Citations

3 citation in other articles

One origin for metallo-β-lactamase activity, or two? An investigation assessing a diverse set of reconstructed ancestral sequences based on a sample of phylogenetic trees.
Alderson et al. (2014)
2 more

1 mention without citation

PUDGE: a flexible, interactive server for protein structure prediction.
Norel et al. (2010)