Function and Biology Details
Reaction catalysed:
6-phospho-D-gluconate + NADP(+) = D-ribulose 5-phosphate + CO(2) + NADPH
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
- 6-phosphogluconate dehydrogenase
- 6-phosphogluconate dehydrogenase, C-terminal
- 6-phosphogluconate dehydrogenase, decarboxylating
- 6-phosphogluconate-binding site
- 6-phosphogluconate dehydrogenase, domain 2
- 6-phosphogluconate dehydrogenase-like, C-terminal domain superfamily
- 6-phosphogluconate dehydrogenase, NADP-binding
- NAD(P)-binding domain superfamily
Structure analysis Details
Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-102220 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
6-phosphogluconate dehydrogenase, decarboxylating
Molecule details ›
Chains: A, B
Length: 480 amino acids
Theoretical weight: 53.08 KDa
Source organism: Klebsiella pneumoniae
Expression system: Escherichia coli BL21(DE3)
UniProt:
Sequence domains:
Length: 480 amino acids
Theoretical weight: 53.08 KDa
Source organism: Klebsiella pneumoniae
Expression system: Escherichia coli BL21(DE3)
UniProt:
- Canonical:
A0A0J9WZ66 (Residues: 1-468; Coverage: 100%)
Sequence domains:
- NAD binding domain of 6-phosphogluconate dehydrogenase
- 6-phosphogluconate dehydrogenase, C-terminal domain
Ligands and Environments
No bound ligands
No modified residues
Experiments and Validation Details
X-ray source:
PHOTON FACTORY BEAMLINE BL-6A
Spacegroup:
P3121
Expression system: Escherichia coli BL21(DE3)
