› 2zzo

X-ray diffraction
2.2Å resolution

Crystal structure of the complex between GP41 fragment N36 and fusion inhibitor C34/S138A

Released:
DOI: 10.2210/pdb2zzo/pdb
PDB entry 2zzo coloured by chain, front view.
PDB entry 2zzo coloured by chain, side view.
PDB entry 2zzo coloured by chain, top view.
Source organism: Human immunodeficiency virus type 1 (BRU ISOLATE)
Primary publication:
X-ray crystallographic study of an HIV-1 fusion inhibitor with the gp41 S138A substitution.
Watabe T, Terakawa Y, Watanabe K, Ohno H, Nakano H, Nakatsu T, Kato H, Izumi K, Kodama E, Matsuoka M, Kitaura K, Oishi S, Fujii N
J Mol Biol 392 657-65 (2009)
PMID: 19616557

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero hexamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-136947 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Transmembrane protein gp41 Chain: N
Molecule details ›
Chain: N
Length: 37 amino acids
Theoretical weight: 4.15 KDa
Source organism: Human immunodeficiency virus type 1 (BRU ISOLATE)
Expression system: Not provided
UniProt:
  • Canonical: P03377 (Residues: 551-586; Coverage: 4%)
Gene name: env
Transmembrane protein gp41 Chain: C
Molecule details ›
Chain: C
Length: 35 amino acids
Theoretical weight: 4.26 KDa
Source organism: Human immunodeficiency virus type 1 (BRU ISOLATE)
Expression system: Not provided
UniProt:
  • Canonical: P03377 (Residues: 632-666; Coverage: 4%)
Gene name: env

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU
Spacegroup: P321
Unit cell:
a: 49.09Å b: 49.09Å c: 56.4Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.215 0.212 0.283
Expression system: Not provided

Quick links

Citations

3 review citations

Current perspectives on HIV-1 antiretroviral drug resistance.
Iyidogan et al. (2014)
2 more

2 mentions without citation

Computer-Aided Approaches for Targeting HIVgp41.
Allen et al. (2012)
1 more