› 304d

X-ray diffraction
1.9Å resolution

SIDE-BY-SIDE BINDING OF DISTAMYCIN MOLECULES TO D(ICATATIC) IN THE MONOCLINIC FORM

Released:
DOI: 10.2210/pdb304d/pdb
PDB entry 304d coloured by chain, front view.
PDB entry 304d coloured by chain, side view.
PDB entry 304d coloured by chain, top view.
Source organism: Synthetic construct
Primary publication:
Crystal structures of the side-by-side binding of distamycin to AT-containing DNA octamers d(ICITACIC) and d(ICATATIC).
Chen X, Ramakrishnan B, Sundaralingam M
J Mol Biol 267 1157-70 (1997)
PMID: 9150404

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-115979 (preferred)
Entry contents:
1 distinct DNA molecule
Macromolecule:
DNA (5'-D(*IP*CP*AP*TP*AP*TP*IP*C)-3') Chain: A
Molecule details ›
Chain: A
Length: 8 nucleotides
Theoretical weight: 2.4 KDa
Source organism: Synthetic construct
Expression system: Not provided

Ligands and Environments

1 bound ligand:
Ligand DMY 1 x DMY
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: C2
Unit cell:
a: 33.38Å b: 25.33Å c: 28.11Å
α: 90° β: 120.45° γ: 90°
R-values:
R R work R free
0.184 0.184 not available
Expression system: Not provided

Quick links

Citations

3 review citations

Effects of anticancer drugs on transcription factor-DNA interactions.
Gniazdowski et al. (2005)
2 more

3 mentions without citation

DNA conformations and their sequence preferences.
Svozil et al. (2008)
2 more