› 358d

X-ray diffraction
2.5Å resolution

CRYSTAL STRUCTURE OF THE 2:1 NETROPSIN-DNA DECAMER D(CBRCCCCIIIII) COMPLEX WITH END-TO-END BINDING

Released:
DOI: 10.2210/pdb358d/pdb
PDB entry 358d coloured by chain, front view.
PDB entry 358d coloured by chain, side view.
PDB entry 358d coloured by chain, top view.
Source organism: Synthetic construct
Primary publication:
A novel end-to-end binding of two netropsins to the DNA decamers d(CCCCCIIIII)2, d(CCCBr5CCIIIII)2and d(CBr5CCCCIIIII)2.
Chen X, Mitra SN, Rao ST, Sekar K, Sundaralingam M
Nucleic Acids Res 26 5464-71 (1998)
PMID: 9826773

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-116023 (preferred)
Entry contents:
1 distinct DNA molecule
Macromolecule:
DNA (5'-D(*CP*(CBR)P*CP*CP*CP*IP*IP*IP*IP*I)-3') Chains: A, B
Molecule details ›
Chains: A, B
Length: 10 nucleotides
Theoretical weight: 3.05 KDa
Source organism: Synthetic construct
Expression system: Not provided

Ligands and Environments

1 bound ligand:
Ligand NT 2 x NT
1 modified residue:
Ligand CBR 2 x CBR

Experiments and Validation Details

Entry percentile scores
Spacegroup: P61
Unit cell:
a: 32.13Å b: 32.13Å c: 143.92Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.211 0.211 0.298
Expression system: Not provided

Quick links

Citations

1 review citation

Recent Advances in Developing Small Molecules Targeting Nucleic Acid.
Wang et al. (2016)
11 other articles

1 mention without citation

Structure-based DNA-targeting strategies with small molecule ligands for drug discovery.
Sheng et al. (2013)