› 360d

X-ray diffraction
1.85Å resolution

STRUCTURE OF 2,5-BIS{[4-(N-ETHYLAMIDINO)PHENYL]}FURAN COMPLEXED TO 5'-D(CPGPCPGPAPAPTPTPCPGPCPG)-3'. A MINOR GROOVE DRUG COMPLEX, SHOWING PATTERNS OF GROOVE HYDRATION

Released:
DOI: 10.2210/pdb360d/pdb
PDB entry 360d coloured by chain, front view.
PDB entry 360d coloured by chain, side view.
PDB entry 360d coloured by chain, top view.
Source organism: synthetic construct
Primary publication:
Visualisation of extensive water ribbons and networks in a DNA minor-groove drug complex.
Guerri A, Simpson IJ, Neidle S
Nucleic Acids Res 26 2873-8 (1998)
PMID: 9611230

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-116024 (preferred)
Entry contents:
1 distinct DNA molecule
Macromolecule:
DNA (5'-D(*CP*GP*CP*GP*AP*AP*TP*TP*CP*GP*CP*G)-3') Chains: A, B
Molecule details ›
Chains: A, B
Length: 12 nucleotides
Theoretical weight: 3.66 KDa
Source organism: synthetic construct
Expression system: Not provided

Ligands and Environments

2 bound ligands:
Ligand MG 1 x MG
Ligand BPF 1 x BPF
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU
Spacegroup: P212121
Unit cell:
a: 24.24Å b: 39.94Å c: 65.88Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.166 0.166 not available
Expression system: Not provided

Quick links

Citations

11 citation in other articles

A thermodynamic and structural analysis of DNA minor-groove complex formation.
Mazur et al. (2000)
10 more

6 mentions without citation

DNA conformations and their sequence preferences.
Svozil et al. (2008)
5 more