› 378d

X-ray diffraction
2.4Å resolution

STRUCTURE OF THE SIDE-BY-SIDE BINDING OF DISTAMYCIN TO DNA

Released:
DOI: 10.2210/pdb378d/pdb
PDB entry 378d coloured by chain, front view.
PDB entry 378d coloured by chain, side view.
PDB entry 378d coloured by chain, top view.
Source organism: Unidentified
Primary publication:
Structure of the side-by-side binding of distamycin to d(GTATATAC)2.
Mitra SN, Wahl MC, Sundaralingam M
Acta Crystallogr D Biol Crystallogr 55 602-9 (1999)
PMID: 10089456

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-116037 (preferred)
Entry contents:
1 distinct DNA molecule
Macromolecule:
DNA (5'-D(*GP*TP*AP*TP*AP*TP*AP*C)-3') Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 8 nucleotides
Theoretical weight: 2.43 KDa
Source organism: Unidentified
Expression system: Not provided

Ligands and Environments

2 bound ligands:
Ligand DMY 4 x DMY
Ligand NA 1 x NA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: MACSCIENCE
Spacegroup: P21
Unit cell:
a: 29.55Å b: 42.18Å c: 43.38Å
α: 90° β: 96.56° γ: 90°
R-values:
R R work R free
0.21 0.21 0.286
Expression system: Not provided

Quick links

Citations

2 review citations

Multitargeted anti-infective drugs: resilience to resistance in the antimicrobial resistance era.
Suckling et al. (2022)
1 more

10 mentions without citation

Structure-based DNA-targeting strategies with small molecule ligands for drug discovery.
Sheng et al. (2013)
9 more