› 389d

X-ray diffraction
1.55Å resolution

CRYSTAL STRUCTURE OF B-DNA WITH INCORPORATED 2'-DEOXY-2'-FLUORO-ARABINO-FURANOSYL THYMINES: IMPLICATIONS OF CONFORMATIONAL PREORGANIZATION FOR DUPLEX STABILITY

Released:
DOI: 10.2210/pdb389d/pdb
PDB entry 389d coloured by chain, front view.
PDB entry 389d coloured by chain, side view.
PDB entry 389d coloured by chain, top view.
Source organism: Unidentified
Primary publication:
Crystal structures of B-DNA with incorporated 2'-deoxy-2'-fluoro-arabino-furanosyl thymines: implications of conformational preorganization for duplex stability.
Berger I, Tereshko V, Ikeda H, Marquez VE, Egli M
Nucleic Acids Res 26 2473-80 (1998)
PMID: 9580702

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-116046 (preferred)
Entry contents:
1 distinct DNA molecule
Macromolecule:
DNA (5'-D(*CP*GP*CP*GP*AP*AP*(TAF)P*TP*CP*GP*CP*G)-3') Chains: A, B
Molecule details ›
Chains: A, B
Length: 12 nucleotides
Theoretical weight: 3.68 KDa
Source organism: Unidentified
Expression system: Not provided

Ligands and Environments

1 bound ligand:
Ligand MG 1 x MG
1 modified residue:
Ligand TAF 2 x TAF

Experiments and Validation Details

Entry percentile scores
Spacegroup: P212121
Unit cell:
a: 25.2Å b: 39.71Å c: 65.68Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.218 0.218 not available
Expression system: Not provided

Quick links

Citations

6 review citations

Designing chemically modified oligonucleotides for targeted gene silencing.
Deleavey et al. (2012)
5 more